Jump to content

  • Log in with Facebook Log in with Twitter Log In with Google Sign In
  • Create Account

Support, help, advice & information for Multiple Sclerosis. Ask questions & share experiences with people affected by MS.

Listeria and alemtuzumab

  • You cannot start a new topic
  • Please log in to reply
No replies to this topic

RSS News

RSS News

    RSS News Feed Reader

  • Staff
  • 5,553 posts
  • Joined: 25-May 08
    Member: 792
  • Gender:Not Telling

Current mood: None chosen
Holmøy T, von der Lippe H, Leegaard TM.Listeria monocytogenes infection associated with alemtuzumab - - a case for better preventive strategies.BMC Neurol. 2017;17(1):65.

BACKGROUND:The mortality of septicaemia, meningitis and encephalitis caused by Listeria monocytogenes is 20-40%. Twenty-one cases of invasive listeriosis associated with alemtuzumab, including at least 16 in patients with multiple sclerosis, have been published or reported to the World Health Organization Case Safety Reports Database. Three cases were fatal, including at least one patient treated for multiple sclerosis in 2016.
CASE PRESENTATION:We report a patient with multiple sclerosis who developed pyrexia, nausea and abdominal discomfort few hours after the third and last infusion of her second alemtuzumab cycle. An infusion related reaction was suspected. The patient had however eaten soft cheese and raw sausage 3 days prior to treatment, and L. monocytogenes septicaemia was diagnosed based on positive blood cultures.
CONCLUSION:Listeriosis associated with alemtuzumab is a potentially fatal condition that can mimic an infusion related reaction. As in most other previously reported cases symptoms started rapidly after the last infusion, suggesting that the patient already carried the bacteria prior to the alemtuzumab infusions. The summary of product characteristics recommends patients to avoid foods associated with listeria at least 1 month after treatment. This recommendation should include also the last weeks prior to treatment.

Yet another case of Listeria on alemtuzumab. But in this case thye were eating non-pastuerised cheese just before removal of all their immune system. Not recomended

View the full article

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users

The MS People Forum is not responsible for advice or information supplied by members. We suggest you seek medical advice before trying anything.
Messages posted within the Forum express only the views of the author of the message and do not necessarily reflect the views of MS-People.com.
MS-People.com nor any person or entity associated with them will be held responsible for the contents, accuracy, completeness or validity of any information posted on the site.