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Support, help, advice and information for Multiple Sclerosis. Ask questions and share experiences with people affected by MS.




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6 links

  1. MS Decisions is a guide to the disease modifying drugs approved for treating relapsing remitting multiple sclerosis in the UK.

    Each drug offers a different combination of benefits and risks. These webpages will help you explore your options and help you discuss starting or switching between one of the drugs with your MS team.
  2. A "Clinic speak" Q+A page by Prof Gavin Giovannoni on the Barts MS Blog website.

    Question: Relapsing/remitting MS for 7 years; 4.5 years on interferon-beta (Rebif) until pregnancy, no medication for 2.5 years, mild symptoms once a year. I have been offered Copaxone by my consultant. Should I start Copaxone?
  3. Sativex was the first cannabis-based medicine to be licensed in the UK. It is licensed for use as an add-on treatment for MS-related spasticity (muscle stiffness) when people have found that other medicines have not worked well or found their side effects intolerable.

    Sativex is a mouth (oromucosal) spray formulated from two chemical extracts derived from the cannabis plant and contains delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabis plants are thought to contain more than 60 such chemicals - known as cannabinoids - but these two specific cannabinoids have been studied for their effects in MS.
  4. Stem cells offer great promise for treating MS and possibly repairing some of the damage caused to the central nervous system.

    This factsheet provides an overview of areas being explored by researchers and some of the studies that have taken place.
  5. The Tysabri saga is one that is of immense interest to the medical and investment communities, as well as to multiple sclerosis patients everywhere. Containing more twists and turns than your average Six Flags theme park ride, Tysabri is known as the “miracle” drug that was, then wasn’t, and now is again.

    Because discussions about Tysabri tend to be inundated with numerous medical and scientific terms and industry jargon, the purpose of this document is to attempt to bring the average “layman” up to speed on all things Tysabri. The hope is not only will the reader gain a familiarity of the Tysabri saga, he or she will obtain enough working knowledge to understand the esoteric Tysabri description set forth above by Natalie.

    To understand how Tysabri works, one must first understand some basics on multiple sclerosis (MS).
  6. Q. What is Waterfall D-Mannose, exactly?

    A. It is not a herbal remedy, but a natural monosaccharide isomer of glucose, extracted from sweet forest timbers (mainly of the hard Fagaceae and Betulaceae families) without using solvents. We only use the best mannose, ensuring that the product works exceptionally well. Also, and very importantly, we have never once taken an order that we could not deliver - usually the next day.

    Q. What types of bacteria is Waterfall D-Mannose effective against?

    A. It appears to be effective against the most common bacterial urinary infection agents (bacteriuria). In particular, it seems to work best against E.coli (the cause of 90%+ of urine infections) and Klebsiella, (the cause of about 5% of urine infections). In fact, common sense says it must work against these bacteria because of the way mannose is known to occupy the mannose receptors that E.coli and Klebsiella rely on for attachment, so bacteria in the urine attach to the free mannose in the urine and can't attach to you.

    It may also work to tease off attached bacteria through bio-molecular attraction, and should also fill any vacant mannose receptors of your own tissue cells in your bladder and urinary tract, preventing fresh bacteria from attaching. We are also getting reports that the product is proving useful against interstitial cystitis.

    Q. What types of bacteria is Waterfall D-Mannose not very effective against?

    A. It does not appear to be effective against Enterococcus, Streptococcus, the Proteus family, or Pseudomonas - a minority of urinary tract infection agents that you are more likely to pick up if, for example, you have recently been for an investigation in hospital, or if you are very immune compromised and have an indwelling catheter. Proteus and the Pseudomonas don't rely completely on mannose attachment, so whilst the product appears to work to some extent against Proteus Mirabilis, (but we think not against Proteus Vulgaris), and Waterfall D-Mannose seems to help prevent it from doing so much damage as normal, (from the fact that customers report that it feels better temporarily) it doesn't seem to completely get rid of it. People say of P.Mirabilis, it 'keeps coming back as soon as I ease back on the Waterfall D-Mannose '. Antibiotics, unfortunately, may be the only solution, although Proteus bacteriuria are very antibiotic resistant.

    That Waterfall D-Mannose works at all on these, may be because the Proteus family also has some minor mannose attachment mechanism. We think the d-mannose interferes with the attachment mechanism in the same way as it does with E.coli and Klebsiella, but because the bacteria can swarm in the mucous membrane of the bladder, and are not reliant on mannose in the same way as E.coli, Klebsiella, and Salmonella, they are harder to flush away.

    In practice, we get hundreds of customers every month saying it has cleared up their problem, and just a few who say it hasn't worked very well for them. When that's happened we've recommended they get their urine tested and have the results faxed to us. In these cases they have usually turned out to have a combination of Streptococcus and Enterococcus. We can't win them all, but we are working on some ideas to defeat these bacteria. Meanwhile an idea that has worked for some people, when antibiotics have repeatedly failed is our glyconutrient mix recipy.

    However, customer feedback tells us that Waterfall D-Mannose does seem to prevent almost all bladder infections when taken as a prophylactic. Very few people who take it long-term as a preventative measure ever get Proteus infections, Pseudomonas infections, or any other urinary infections, and that, as they say, is the proof of the pudding. You can prove that for yourself just by trying it.

About Us

Founded in 2004, MS People UK is a community website and discussion forum by and for people with Multiple Sclerosis as well as for friends, families, supporters and those interested in this disabling condition.

If you’re newly diagnosed or want to ask about possible first symptoms, or if you’ve had Relapse Remit, Secondary or Primary Progressive MS for some time, a welcoming group of fellow MS sufferers is here to chat with you about MS symptoms, diagnosis and treatments.

The atmosphere is friendly whilst being compassionate, supportive and caring. Members also post about a variety of subjects not related to MS, as well as share jokes, talk about their hobbies, have fun, and more.

The MS People Forum is not responsible for advice or information supplied by members. We suggest you seek medical advice before trying anything.