As someone who's been very interested to follow the research currently being carried out on CCSVI, and given its something lots of people have debated on this forum, I thought it would be interesting to post the latest news.
The largest study to date testing the venous-obstruction theory of multiple sclerosis failed to support it, leading the Italian Multiple Sclerosis Society to declare the theory dead.Reported here by leaders of the group, known by its Italian abbreviation AISM, the study of nearly 2,000 individuals with blinded central imaging analysis found the condition in only about 3% of MS patients and in only slightly fewer healthy controls or patients with other neurological conditions.Key data were released at a press briefing by principal investigator Giancarlo Comi, MD, of the University of Milan, and other study leaders in advance of Comi's formal presentation, scheduled for Saturday at the annual meeting of the European Committee for Treatment and Research in Multiple Sclerosis.They characterized the study as the largest yet conducted on the so-called chronic cerebrospinal venous insufficiency theory ( CCSVI), advanced in 2009 by Paolo Zamboni, MD, of the University of Ferrara in Italy.The CCSVI theory quickly took the MS community by storm, leading many patients to seek venous angioplasty and stenting procedures in hope of obtaining relief or even a cure, as Zamboni and some other vascular surgeons claimed was possible.But the theory also drew substantial criticism, especially after numerous other researchers were unable to reproduce Zamboni's original findings of 100% presence of CCSVI in MS patients and 0% in non-MS controls. Some groups were unable to detect CCSVI in more than a small fraction of patients, while others found that it was relatively common but without specificity for MS.In the new study, sponsored by AISM and called CoSMo, ultrasound analyses were performed on 1,874 individuals at 35 clinics throughout Italy. A total of 107 were subsequently excluded because of technical problems with the images or because participants were found not to meet the specified inclusion criteria (such as age or disease duration)....
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Just to let you know for anyone who's interested, an item is on You and Yours on Radio 4 about CCSVI. You'll be able to access it on iPlayer if it's too late. xx.
For anyone interested in CCSVI Canada is going to run a trial early next year
See link
http://www.cbc.ca/news/politics/story/2011/11/25/pol-ms-clinical-trials.html
Not sure if the link works from copying it but it's from CBC news website
But the strange thing is I don't have MS!
I have been a member here since 2009 but thought I should 'reintroduce' myself as I only made two posts before.
I can on in a bit of a tizz as I have been living with weird symptoms for some time and no answers. Brain fog, memory loss, depersonalisation, dizziness that borders on vertigo, tinnitus and loss of hearing, numbness/weaknesses/alterned sensations down my right side, crawling sensations and probably loads more that I've forgotten!
I've seen 4 neurologists and 1 neurosurgeon and had the whole raft of tests ( MRI, MRV, MRA, LP, EEG, ECG etc) and nothing showing MS even though the neurosurgeon felt I had a demylinating disease after he examined me (the most thorough examination of all the specialists so far too) but the tests again were normal.
What my MRV did show was a problem with my transverse sinus vein, but this was deemed to be an abnormal variation.
Anyway, to cut a very long story short eventually I put myself on the list for CCSVI testing and had it done this morning, with a positive result.
Both my internal jugular veins are stenosed and both the valves are malformed. The right internal jugular vein is collapsed in the erect position and does not expand in the supine position. A marked reduction of flow velocity in the both veins and a significant mid stenotic lesion on the right.
I just wanted to come back here and post my update. I will of course post more when I have the procedure done but that won't be for a few months yet.
CindyCB. x
Conclusions from ISNVD Bologna
by ms- ccsvi-uk on Monday, 21 March 2011 at 14:49
This is a potted version of what took place at Bologna on the 15th and 16th March. Courtesy of MSRC
Many of the issues which are still open on the relationship between CCSVI and MS found an answer at the ISNVD (International Society for Neurovascular Disease) Annual Meeting. The Society, chaired by Prof. Paolo Zamboni, held its meeting in Bologna (Italy) on March 14-15, 2011 under the High Patronage of the President of the Italian Republic.
The Meeting
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