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ASCEND Trial - A Failure?

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John aka Stumbler (as I do fall over!)

Illegitimi non carborundum


"Life is not a journey to the grave with the intention of arriving safely in a pretty and well-preserved body, but rather to skid in broadside, thoroughly used up, totally worn out, and loudly proclaiming... "Wow! What a ride!"

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Thanks for that John,


Yes I was on that trail, and the link you've sent makes really interesting reading.

 During most of the trail it was 'double blind' so nobody knew who was on the drug and who was using the placebo. For myself I could detect no change in my own condition, and again in the last six months of the trail, when I was on the drug, I saw little change.

 Now that in itself is interesting,  My EDSS when first diagnosed 11 years ago was around 4.5 by the time of the end of the trail it was 6 (Much the same as at the trails start)  Those were formal assessments, today I would gauge my level of disability remains at around the same EDSS 6 level.   Is this the 'lag' factor mentioned in the Bart report?  I had felt very lucky that my MS had not progressed quickly, putting some of that down to positive attitude and sheer good fortune.

 Of course the down side to all this is that if I had been taking Natalizumab all the way through the trail (2 1/2 years) and it has been effective then am I about to see the end of the Lag?


In any event, many thanks for passing the information on.





Just another Warrior...........

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