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SPMS help

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Hello everybody. I have SPMS and have horrendous pain in my legs - has anyone any advice or suggestions for medication that might help? I already take Duloxetine and Pregabalin at their maximum dose.

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Hi @MrsCB,


Duloxetine and Pregabalin are OK-ish for sensory pain, e.g. the burning, itching, pins & needles, etc. They're not so good for musculo-skeletal pain.


The different causes of pain have different treatments. The following might help :-






Do contact your MS Nurse to  discuss this issue further.



John aka Stumbler (as I do fall over!)

Illegitimi non carborundum


"Life is not a journey to the grave with the intention of arriving safely in a pretty and well-preserved body, but rather to skid in broadside, thoroughly used up, totally worn out, and loudly proclaiming... "Wow! What a ride!"

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Hi Mrs CB

It sounds like you suffer the same horrendous leg pain as myself.. and it IS nothing short of horrendous! Neuropathic pain...I take very little pregabalin as I can't tolerate it.. I know it might sound daft but the only thing that maybe helps me.. I like to think it does.. now and again i get a bit of respite from the pain... I'm in agony as I type...is folic acid.. i take 400ug a day without fail and altho the pain is hellish bad it seems worse if i dont take it... maybe its all in my head.. but if nothing else i do know what your going through... please check with Dr or ms nurse if you decide to give it a go. 


Regards Fran

Edited by Softsqueezy
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