Stopping ms progression

[saf0113]

http://www.theaustralian.com.au/news/breaking-news-old/discovery-could-halt-ms-progression/story-fn3dxity-1226338953415

[Scully]

We can only keep our fingers firmly crossed !

 

It's always exciting when we hear of seemingly breakthroughs to combat, cure or halt this disease.

 

We always live in hope.

 

Scully

x

[Bigbird]

Wonder why Melbourne/Monash uni is doing so much research in this area. Funnily enough I was diagnosed in Melbourne when we lived there. Think we should have stayed.

I want to be on any trial they are doing!

[Tania B]

How do you know that you've reached a progressive stage of MS?

[Bigbird]

Well I was told by my consultant when I just kept getting progressively worse and never returning to a point I was previously, if that makes sense. What I mean is I didn't have a bad time then got better then had another bad time later. I just became progressively worse.

[Tania B]

What if you get a bit better but do not return to how you were?

[Bigbird]

You don't always return to where you were but you'll get a bit better than you were at your worst or at least stop getting worse for a while. Whereas progressive you just keep on going. For some of us it's faster than others. Or that's how it is for me. When I was RRMS I had years of remission and the relapses weren't too bad. Now I'm SPMS it's all progressing slowly too.

[derby42]

wow thanks for that from me too. you explained that really well cos i don't know where the hell i am with all this.

[HeidelsCorner]

Wow - that's an interesting article. Wonder if there are any trials of this kind going on in the UK? I got a shock when I visited my neuro last as I thought when I recovered from a relapse I'd go back to where I was before but she said this isn't the case. I hadn't realised this and had been panicking why I hadn't 'bounced back' as I had expected to do. It's certainly a steep learning curve we are on!

[tedhutchinson]

The research this article is referring to is called "

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation

"

The research abstract is available but the full text isn't.

That Crmp2 phosphorylation is also implicated in Alzheimer's progression and we know from earlier work that it's the beta-amyloid protein that's implicated in this phosphorylation. We can clear or reduce beta-amyloid protein with both Vitamin D3 and CURCUMIN. There is plenty of recent research that shows these simple/cheap supplements help clear beta-amyloid.

There is also work showing how Retinoic acid (RA), acting through the RA receptor β (RAR-β), inhibited myelin-activated Nogo receptor NgR signaling.

So it looks like LIVER may be a useful addition to the menu.

You may also be pleased to know that the new paper

"Nutrient intake and plasma β-amyloid." says "Our data suggest that higher dietary intake of ω-3 PUFA is associated with lower plasma levels of Aβ42, a profile linked with reduced risk of incident AD and slower cognitive decline in our cohort.

 

so if we want to block or slow or inhibit the phosphorylation of CRMP-2 then reducing plasma β-amyloid.is a step in the right direction. .Direct MS suggest Omega 3 Essential Fatty Acids: 5 g of EPA+DHA which is a lot of capsules. I prefer a liquid fish oil the one I use provides 1,150 mg omega 3 per teaspoon. I just take a couple of teaspoons daily.

Edited 10 May 2012, 4:11 pm by tedhutchinson